Nick Kyrgios has seen off American wildcard JJ Wolf with a minimum of fuss to quietly progress to the US Open second week for the first time.

Playing second fiddle for once to fellow Australian tennis star and former girlfriend Ajla Tomljanovic, Kyrgios dispatched Wolf 6-4 6-2 6-3 to set up a likely fourth-round showdown with world No.1 and defending champion Daniil Medvedev.

WATCH IN THE VIDEO ABOVE: Kyrgios speaks after US Open win

Watch the latest sport on Channel 7 or stream for free on 7plus >>

Ushered on to Louis Armstrong the same time as Tomljanovic arrived at Arthur Ashe Stadium to face retiring great Serena Williams, Kyrgios wasted only three sets and less than two hours on court.

The Wimbledon finalist will likely need every ounce of energy for his last-16 match.

Barring an upset loss to Chinese qualifier Wu Yibling later on Friday night (Saturday AEST), Kyrgios will square off with Medvedev in the first heavyweight battle of the Open.

Kyrgios leads the Russian 3-1 head to head and upstaged the top seed only three weeks ago in Montreal.

If anyone can deny Medvedev back-to-back titles at Flushing Meadows, especially in Novak Djokovic’s absence, it’s the mercurial Kyrgios.

A last-16 clash on Sunday would be worthy of a final, with officials unhappy to lose either of the two big drawcards before the quarter-finals stage.

Tomljanovic is also through to the last 16 in New York for the first time following her emotion-charged 7-5 6-7 (4-7) 6-1 third-round triumph over Williams.

Unlike Kyrgios’s cakewalk, Tomljanovic needed three hours, five minutes, six match points and the performance of her life to send Williams into retirement.

Ajla Tomlijanovic celebrates after defeating Serena Williams in the third round of the US Open at the Billie Jean King National Tennis Centre. Credit: Getty Images

A two-time Wimbledon quarter-finalist, Tomljanovic’s reward is a clash with red-hot Russian Lludmila Samsonova on Sunday for a place in the last eight in consecutive grand slams.

Kyrgios and Tomljanovic are Australia’s last two survivors in the singles draws after Alex de Minaur suffered a 6-1 6-1 3-6 7-6 (7-5) third-round loss to Spanish 12th seed Pablo Carreno Busta.

– with AAP

Serena takes final bow after Aussie’s US Open stunner.

Serena takes final bow after Aussie’s US Open stunner.