BALTIMORE (AP) — Alek Manoah retired 22 of his final 23 hitters in an impressive eight-inning performance, and the Toronto Blue Jays wrapped up a successful series in Baltimore with a 4-1 victory over the Orioles on Wednesday night.

The Blue Jays won three of four to take a 4 1/2-game lead on Baltimore for the last wild card in the American League. Manoah (14-7) allowed a run in the first, but the Orioles didn’t manage another baserunner until the sixth.

Toronto scored three times in the fifth off Dean Kremer (6-5) and left Camden Yards with its postseason chances looking pretty good — although these two teams have six more games scheduled against each other.

The Orioles took a 1-0 lead on Ryan Mountcastle’s RBI double, but the final out of the first started a streak of 14 in a row retired by Manoah. The All-Star right-hander allowed three hits and a walk, striking out five. Jordan Romano struck out two in a perfect ninth for his 31st save in 35 chances.

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Baltimore reinstated Tyler Wells from the injured list and had him pitch the first two innings as basically an opener. He got in a jam in the second and allowed an RBI grounder by Lourdes Gurriel Jr. to tie it.

Kremer retired the Blue Jays in order in the third and fourth, but the fifth started badly for him when the bottom two hitters in Toronto’s lineup singled. One out later, Vladimir Guerrero Jr. made it 2-1 with an RBI groundout. After a walk to Bo Bichette, Alejandro Kirk hit a flare to left for a run-scoring single.

Rookie catcher Adley Rutschman then gifted the Blue Jays another run when he tried to pick off Kirk at first and threw wildly for an error.

Kremer allowed two earned runs and six hits in 5 1/3 innings.

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Kirk had three hits.

SMOOTH

Guerrero went just 1 for 5 but contributed defensively when he made a behind-the-back toss to Manoah covering first on Rutschman’s grounder in the third.

TRAINER’S ROOM

Blue Jays: Gurriel exited with left hamstring discomfort after hustling to first to beat out a potential double play in the second. … The Blue Jays were without OF Teoscar Hernández, who went on the paternity list. Toronto recalled RHP Zach Pop and C Gabriel Moreno from Triple-A Buffalo and optioned RHP Mitch White to Buffalo.

Orioles: RHP Jordan Lyles, scratched from a start Monday because he was feeling sick, was back at the ballpark. Manager Brandon Hyde said he hopes Lyles can pitch this weekend. … Baltimore optioned RHP Spenser Watkins to Triple-A Norfolk as the corresponding move when Wells was activated.

UP NEXT

Both teams have Thursday off. Toronto heads to Texas to face the Rangers on Friday night. Ross Stripling (7-4) starts that game for the Blue Jays.

The Orioles host a three-game series against Boston. Austin Voth (4-2) takes the mound in the opener for Baltimore against Brayan Bello (1-4).

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