Andy Murray has pulled out of his third-round clash with Novak Djokovic at the Madrid Open because of illness.

It is another unfortunate blow for the former world No.1, who defeated Denis Shapovalov on Tuesday for one of the best wins of his comeback and had been looking forward to a first clash with his long-time rival for more than five years.

A post on the tournament’s Twitter feed read: “Unfortunately, Andy Murray is unable to take to the Manolo Santana Stadium due to illness. We wish you a speedy recovery Andy Murray!”

Murray reversed his decision to skip the clay-court season by taking a wild card for Madrid and showed impressive form, defeating Dominic Thiem in the first round and then 14th seed Shapovalov.

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Provided he recovers in time, Murray must now decide whether to play in qualifying for next week’s Italian Open, while the French Open is still potentially on the table despite the Scot previously saying he would not play and would instead concentrate on preparing for the grass-court season.